What is MRONJ?

MRONJ (Medication Related Osteonecrosis of the Jaw) replaces the name of the condition formerly known as BRONJ (Bisphosphonate-Related Osteonecrosis of the Jaw). Osteonecrosis of the jaw, or death of the jaw bone, has been associated with drugs used to prevent osteoporosis or used to treat a form of cancer. MRONJ is a side effect of bisphosphonate and antiresorptive medication therapy.


The name change includes antiresorptive (denosumab) and antiangiogenic drugs that can also cause necrosis of the jaw, as seen with bisphosphonates which are used to prevent or treat osteoporosis.

MRONJ Symptoms:

MRONJ usually appears as exposed bone in the mouth; other symptoms include localized pain, swollen gum tissues and loosened teeth.

Risk Factors:

  • The use of bisphosphonates or antiresorptive drugs: The dosage and length of therapy are the main factors.
  • IV bisphosphonates: Risk appears to increase with the number of treatments.
  • Dental procedures: Approximately 60% of MRONJ cases are due to procedures such as extractions, dental implants or periodontal surgery when a patient is being treated with bisphosphonates.

If you are being treated with bisphosphonates, please schedule regular dental exams so any problems can be identified early. Additionally, take a few extra moments to examine for signs of MRONJ (pain, swelling and exposed bone) so that we can diagnose and treat the condition as soon as possible.

Have Questions?

If you think you have BRONJ or MRONJ, call the office David K. Buran Dentistry today. We are a family dentist office that has been serving the Powder Springs area for 25 years! Call today to schedule your appointment!

David K. Buran, DMD – (770) 943-0701